The Irish rider rode Theo 160 to the win in a field of 52 ; Canada's Mario Deslauriers has two in the top 10.
Thunderbird Show Park's Odlum Brown BC Open starts June 1st and also features the $235,000 Longines Grand Prix.
Thunderbird Show Park was the site of the $200,000 team competition, won by Eugenio Garza Perez, Ashlee Bond and Bliss Heers.
The Irish rider rode Nadal Hero & DB to the stallion's second 5* win of the week; Canadian Anya Bereznicki dominates U25 division.
The Irishman aboard Ariso bested a 10-horse jumpoff; Vanessa Mannix and Kingston are the top Canadians in 8th place.
American Tanner Korotkin captures the 1.40m CSI5*; Canadian Maddy Riddle wins the 1.40m CSI2* in Langley, BC.
"I try to protect him now and just really aim for the classes that matter," said Tiffany of the 15-year-old gelding winning the final grand prix of the season at Tbird.
Vanessa Mannix (CAN) finished second with Balzane du Mazes, while Brennan's fiancée Lauren Crooks (USA) finished third.
A previous series winner, she reclaimed the title with Havana, a horse she has developed herself since the mare was four years old.
The Irishman kicked off the North American League with a convincing victory aboard Vital Chance de la Roque, edging Canada's Vanessa Mannix.