The Irish rider rode Theo 160 to the win in a field of 52 ; Canada's Mario Deslauriers has two in the top 10.
Thunderbird Show Park's Odlum Brown BC Open starts June 1st and also features the $235,000 Longines Grand Prix.
Thunderbird Show Park was the site of the $200,000 team competition, won by Eugenio Garza Perez, Ashlee Bond and Bliss Heers.
The Irishman aboard Ariso bested a 10-horse jumpoff; Vanessa Mannix and Kingston are the top Canadians in 8th place.
American Tanner Korotkin captures the 1.40m CSI5*; Canadian Maddy Riddle wins the 1.40m CSI2* in Langley, BC.
"I try to protect him now and just really aim for the classes that matter," said Tiffany of the 15-year-old gelding winning the final grand prix of the season at Tbird.
The Canadian rider steps up from a win in the U25 last week to record her first senior FEI victory in the $36,900 CSI2* 1.45m class.
Vanessa Mannix (CAN) finished second with Balzane du Mazes, while Brennan's fiancée Lauren Crooks (USA) finished third.
A previous series winner, she reclaimed the title with Havana, a horse she has developed herself since the mare was four years old.
The pair lead wire-to-wire in the $15,000 CSI4*-W 1.45m at Thunderbird Show Park's Harvest Celebration over Justin Prather and EZ Ace.